Sunifiram Review: The Benefits Of Using Sunifiram As A Cognitive Enhancer
Also commonly referred to as DM235, Sunifiram is a relatively new product in the nootropics marketplace, which provides a strong cognitive boost to the users, apart from delivering significant energy and mood enhancement.
Synthesized for the first time in the year 2000, it hasn’t been around for as long as some of the other popular nootropics and the body of research around it is also somewhat limited.
However, preliminary studies have indicated that it does have effective nootropic abilities and can improve memory retention and learning abilities in the users.
Let’s understand how nootropic enthusiasts are benefiting from Sunifiram experience and learn more about its workings.
Apart from its usage as a nootropic, Sunifiram is also being used as a potential treatment alternative for all kinds of neurological disorders including the likes of amnesia, Parkinson’s disease, and Alzheimer’s disease.
The users of this nootropic haven’t reported any serious side effects from it as yet, though the research regarding it is still an ongoing process.
No documented clinical trials or clinical studies have yet been conducted on humans, but animal studies strongly indicate that this substance is well tolerated and safe, and also has less toxicity compared to the racetams.
Sunifiram is derived from the racetam category of nootropics, though its chemical structure is different from them, the reason why it is classified as a type of piperazine alkaloid, rather than an authentic racetam.
The positive effects delivered by it in relation to learning and memory enhancement are same as that of piracetam, however, with 1000 times more potency.
Please note, Sunifiram is also a type of ampakine, which interacts with glutamatergic AMPA receptors in the brain, and boosts the activity of glutamine neurotransmitters, with the possibility of delivering major improvement in energy and mood levels, apart from offering cognitive benefits.
Benefits of Using Sunifiram:
Regular intake of Sunifiram, as per its prescribed dosages can deliver a good variety of benefits, including the following:
Boost in Energy Levels and Overall Mood:
Many users who consume Sunifiram on a regular basis report a significant improvement in their energy levels and overall mood.
As suggested by the reports, they experience a brighter, energetic and an overall happier outlook towards life.
Memory and Learning Boost:
As Sunifiram is a proven and potent nootropic, it delivers measurable improvement in the memory recall and learning speed of the users.
Various animal studies have revealed that not only does it enhance performance in the learning-related tasks, it also reverses the chemically-induced amnesia.
Improved Sex Drive:
A large majority of Sunifiram users witness noticeable and distinguished aphrodisiac properties of this substance. It improves their libido and overall interest in sexual activities.
However, please note, this effect isn’t universal in nature, and hasn’t been tried out in the animal studies yet.
Better Motivation and Focus Levels:
Sunifiram users also report improvement in their motivation, concentration and focus levels, helping them tackle as well as complete all kinds of mental tasks.
Studies carried out on animals have successfully proven this ability of Sunifiram.
The boost in the motivation and focus levels can be attributed to the ability of Sunifiram to facilitate the release of acetylcholine in the brain, a neurotransmitter that is majorly responsible for cognitive abilities.
Effective Depression and Anxiety Management:
Although no animal studies have been conducted so far to directly study Sunifiram’s anti anxiety or antidepressant properties, the users of this substance regularly report such positive effects.
These results can be explained partially because of its ampakine-related actions; ampakine is a compound which interacts with the brain’s glutamatergic AMPA receptors, functioning as a soft stimulant.
Enhancement of Perceptual and Visual Abilities:
Although reports of such perceptual and visual enhancements aren’t universal, many people who consume Sunifiram regularly say that it delivers a brighter outlook towards life, in the literal sense.
You can see shadow and light far more pronounced than usual, and the colors become more vibrant.
In some cases, people also start finding music to be more impactful at both emotional and mental level.
How Sunifiram Works:
Despite being a piracetam derivative, Sunifiram’s chemical structure is quite different from the racetams.
If we talk about its chemistry, it is classified as a type of piperazine alkaloid.
Sunifiram functions in two different ways, one in the form of an ampakine which stimulates the glutamine receptors’ activity in the brain, and in the form of a cholinergic which boosts the production as well as the release of acetylcholine in the brain.
As is the case with a vast majority of nootropics, the precise action mechanisms of Sunifiram are not comprehensively understood by the scientific community.
But its primary effects are believed to be quite like an ampakine, implying that it binds with the brain’s AMPA-type of glutamate receptors, after getting past the blood-brain barrier.
This action of Sunifiram boasts glutamate production in the brain, an important neurotransmitter which plays a critical role in the neural activation.
A type of excitatory neurotransmitter, glutamate is very important for synaptic plasticity (which is to do with how nerve synapses respond to decreases or increases in their activity).
Maintenance of glutamate levels in the brain is essential for both lasting increase and long-term potentiation of the signal-strengths between various neurons.
The levels of glutamate in the brain are of specific importance to the hippocampus, a brain component that plays a major role in memory formation, memory storage, and spatial navigation.
Scientists believe that Sunifiram’s cognition-improvement abilities are achieved by improvement of the neural signal strength in particularly this area of the human brain.
Apart from improving memory formation and memory recall, ampakines function as mild stimulants too, increasing the energy and alertness levels of the users, without causing restlessness or any other negative side effects (that are normally associated with amphetamines, methylphenidate, and caffeine).
Sunifiram also functions as an effective cholinergic, catalyzing the production as well as the release of acetylcholine.
Although scientists haven’t been able to identify the exact process responsible for this phenomenon.
A study carried out on animals in Italy revealed that tests carried out using piperazine compounds like Sunifiram resulted in cholinergic effects, same as that were witnessed with piracetam supplementation.
Acetylcholine is a neurotransmitter that is held majorly responsible for various aspects of the brain, including learning speed, memory formation, memory retention, cognition, ability to solve complex problems without depending on any learned behavior and fluid intelligence.
Majority of the nootropics available in the marketplace today work at least partially through improving the production and release of acetylcholine in the brain, either through stimulation of acetylcholine receptors or through direct supply of choline, its precursor, which gets synthesized into acetylcholine thereafter.
Side Effects of Using Sunifiram:
No harmful or serious side effects have so far been reported because of Sunifiram consumption. Information available from animal studies suggest that Sunifiram is both well-tolerated and safe for human use.
Even when consumed in high dosages, Sunifiram hasn’t been found to have any toxic effects.
A few side effects reported by users are temporary and minor in nature, and include nasal stuffiness, insomnia, increasing perspiration, headache, increase in sensitivity to audio and visual stimulation, salivation and higher body temperature.
On the whole, Sunifiram is a pretty safe supplement for human usage.
Having said that, care should be taken that you consult a qualified doctor before starting Sunifiram usage, especially if you’re already suffering from a health condition.
Nursing and pregnant mothers should also avoid Sunifiram use.
Proper Dosage of Sunifiram:
As mentioned earlier, Sunifiram studies conducted and documented till date have only been on animals, instead of human subjects.
Hence, making it hard to provide any clinically-backed recommendation with regards to its dosage.
It’s a well-known fact that Sunifiram has a far higher potency than racetams.
In fact, a study carried out in this regard revealed that Sunifiram’s potency is 1000 times higher than piracetam.
Owing to its high potency, Sunifiram is prescribed in comparatively smaller dosages than the racetams.
Inferences drawn from the animal studies and actual user-reports suggest that a Sunifiram dosage of around 5 mg - 10 mg, max thrice a day, is considered effective as well as safe.
Sunifiram works best when consumed sublingually, ensuring maximum absorption.
Anyone interested in Sunifiram supplementation, must ideally start with smallest Sunifiram dosage, and increase it gradually based on his/her requirements.
This approach is particularly advisable in case of Sunifiram. Please also note that your body may develop a certain degree of tolerance towards Sunifiram with its daily consumption.
Hence many users preferred having Sunifiram in the form of a stack with other nootropics and cycle it regularly to avoid such tolerance building.
You can effectively stack Sunifiram with many different nootropics, but it’s advisable to exercise caution and conservativeness with regard to dosages of such Sunifiram stacks.
As it’s highly potent in nature, when combined with other potent supplements, you can never be sure how Sunifiram would react and deliver results to your body.
Nevertheless, certain Sunifiram stacks have found to be particularly effective and are in common use among the nootropic enthusiasts. Let’s go over them below:
1. Sunifiram Stack for Enhancement of Cognitive Abilities:
By far the most commonly used Sunifiram stack, it is achieved by combining Sunifiram with either of the popular racetams like noopept, oxiracetam, and piracetam.
As racetams have a powerful impact on the choline stores inside the brain, you should also include some efficient choline source like centrophenoxine, Alpha GPC or CDP-choline to any Sunifiram stack.
2. Sunifiram Stack for Mood Enhancement :
Sunifiram is known to stack pretty well with aniracetam if needed for mood enhancement purposes.
You can also include L theanine in this stack, which boosts the production of GABA, serotonin and dopamine levels in the body, apart from functioning as a glutamine reuptake inhibitor.
Another effective addition to such stack could be Sulbutiamine, which improves the glutamatergic, dopaminergic and cholinergic transmission.
As is the case with any good racetam supplement, it is always advisable to include a good source of choline in it, both for potentiating purposes and for prevention of any unwanted side effects like headaches.
As with the earlier Sunifiram stack, you could use centrophenoxine, Alpha GPC or CDP-choline for this purpose as well.
Where Can You Get Sunifiram?
Unlike other popular nootropics in the marketplace, Sunifiram cannot be found and purchased easily.
It is only available with very few vendors on the Internet, in the form of Sunifiram capsules.
Sunifiram can be easily considered as one among the most promising and exciting nootropic supplements of the recent times, capable of delivering tremendous energy, mood, cognitive and perceptual benefits.
Although it isn’t as popular as some of the more conventional nootropics in the market, it has quickly become a huge favorite of many nootropic enthusiasts, who have started using it on a regular basis.
However, it’s not a nootropic supplement which you can consume carelessly.
Although many animal studies carried out on Sunifiram experience and usage, over the last one and a half decade have revealed that it is non-toxic, well-tolerated and safe for human consumption, it’s always better to exercise caution while consuming any such supplements.
On the whole, Sunifiram comes as a breath of fresh air in a market inundated with all kinds of nootropics.
Hope this Sunifiram review will help you make a well-informed decision about its purchase.